Associate Professor Walker is a researcher at the University of Otago Christchurch. His research programme is focussed on evaluating the clinical significance of genetic variants and developing novel strategies for preventing cancer in high-risk individuals.
He leads the New Zealand Familial Breast Cancer Study, which is the New Zealand node of the international ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles) and CIMBA (Consortium of Investigators of Modifiers of BRCA1/2) consortia. He is also a co-Director of the University of Otago Research Centre, Genetics Otago, and a member of several international groups tasked with improving diagnostic guidelines used to classify genetic variants. These roles include ENIGMA Splicing Working Group Chair, and member of the ENIGMA Steering Committee and Variant Curation Expert Panel, the ClinGen Hereditary Breast Ovarian and Pancreatic Cancer Variant Curation Expert Panel, the ClinGen Sequence Variant Interpretation - Splicing Sub-group, and the BRCA Challenge Steering Group.